Fairly new Software that i'm using and I can't do without:

X1 - E-mail and file search engine. ($99)
Mozilla Firefox plus related extensions and themes - Awesome browser that can be very customized with functionality and interface, and it's not made by Microsoft (Free)
Java Web Album - Creates web-based photo albums for digital pictures. (Free)
Evil Lyrics - Ties in with your media player and displays the lyrics to whatever music you're playing (Free).